中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (34): 6389-6392.doi: 10.3969/j.issn. 2095-4344.2012.34. 024

• 组织构建综述 tissue construction review • 上一篇    下一篇

壳聚糖水凝胶在生物医学材料方面的研究进展

秦颖哲，林 强   

  1. 北京联合大学应用文理学院，北京市 100191
  • 收稿日期:2011-12-28 修回日期:2012-03-05 出版日期:2012-08-19 发布日期:2012-08-19
  • 通讯作者: 林强，博士，硕士生导师，副院长，教授，北京联合大学应用文理学院，北京市 100191
  • 作者简介:秦颖哲★，女，1986年生，广西壮族自治区柳州市人，汉族，北京联合大学在读硕士。 qyz19861024@ 126.com

Research progress of chitosan hydrogel in the field of biomedical materials

Qin Ying-zhe, Lin Qiang   

  1. Applied Arts and Sciences Institute of Beijing Union University, Beijing 100191, China
  • Received:2011-12-28 Revised:2012-03-05 Online:2012-08-19 Published:2012-08-19
  • Contact: Lin Qiang, Doctor, Master’s supervisor, Professor, Applied Arts and Sciences Institute of Beijing Union University, Beijing 100191, China
  • About author:Qin Ying-zhe★, Studying for master’s degree, Applied Arts and Sciences Institute of Beijing Union University, Beijing 100191, China qyz19861024@ 126.com

PDF

516

被引次数

13

摘要：

背景：壳聚糖类水凝胶具有低毒、良好的生物相容性和生物降解性等生物特性。
目的：综述壳聚糖水凝胶在药物控释、组织工程、生物传感器等方面的研究进展。
方法：由第一作者检索2002/2011 Springer电子期刊数据库及中国学术期刊全文数据库有关壳聚糖水凝胶在生物医学材料应用方面的文献。
结果与结论：壳聚糖类水凝胶对温度或pH值等敏感，对药物、蛋白质影响不大。通过改性或与其他高分子复合形成凝胶，可明显改善和提高壳聚糖水凝胶的物理性能，目前已被广泛应用于药物控释、组织工程、生物传感器等生物医学领域。鉴于壳聚糖具有远大的生物潜能，更多方面的研发有待于完成。

关键词: 壳聚糖, 水凝胶, 药物控释, 组织工程, 生物传感器

Abstract:

BACKGROUND: Chitosan hydrogel exhibits several favorable biological properties such as low toxicity, good biocompatibility and biodegradation.
OBJECTIVE: To review the applications of chitosan hydrogel in controlled drug delivery, tissue engineering, and biosensors.
METHODS: The first author searched Springer electronic journals and CNKI database to retrieve the literatures about chitosan hydrogel used in biomedical materials from 2002 to 2011.
RESULTS AND CONCLUSION: Chitosan hydrogel is sensitive to temperature or pH, but has little influence on drugs and proteins. The physical properties of chitosan hydrogen can be improved and enhanced by modification or/and combination with other polymer composites. To date, chitosan hydrogel has been widely used in controlled drug delivery, tissue engineering, biosensors and other biomedical fields. In view of its great biological potential, chitosan hydrogen need to be further studied.

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